Reaction of indole-2,3-dicarboxylic anhydride with (3-bromo-4-pyridyl)triisopropoxytitanium: Synthesis of ellipticine

Autor:	Yasuyoshi Miki, Hiroko Hachiken, Yoshitaka Tada, Ko-ichi Matsushita, Norihide Yanase
Rok vydání:	1996
Předmět:	Ellipticine Indole test Chemistry Product (mathematics) Yield (chemistry) Organic Chemistry Drug Discovery Biochemistry Medicinal chemistry
Zdroj:	Tetrahedron Letters. 37:7753-7754
ISSN:	0040-4039
DOI:	10.1016/0040-4039(96)01768-6
Popis:	N -Benzylindole-2,3-dicarboxylic anhydride ( 1 ) was reacted with (3-bromo-4-pyridyl)triisopropoxytitanium to give 2-(3-bromoisonicotinoyl)indole-3-carboxylic acid ( 2 ) as the sole product in high yield, which could be converted to ellipticine in six steps.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::81a59ca58d06d5c1d71d2449a878ba1f https://doi.org/10.1016/0040-4039(96)01768-6 Zobrazit plný text záznamu Full Text from ScienceDirect