Chemical Constituents from the Leaves of Pachyrhizus erosus Collected in Vietnam

Autor:	Hoang Thi Lan Anh, Ho Khanh Toan, Tran Thi Minh, Do Thi Thao, Tran Thu Huong, Vu Dinh Hoang
Rok vydání:	2021
Předmět:	chemistry.chemical_classification biology Traditional medicine Glycoside General Chemistry General Medicine Fabaceae biology.organism_classification Prenylated chalcone chemistry Phytochemical Pachyrhizus Chemical constituents Drug Discovery Epimer Lactone
Zdroj:	Chemical and Pharmaceutical Bulletin. 69:1136-1139
ISSN:	1347-5223 0009-2363
Popis:	A phytochemical investigation of methanol extract from leaves of Pachyrhizus erosus (L.) Urban, a leguminous shrub distributed in Vietnam and other tropical and subtropical countries led to the isolation of a new prenylated chalcone, erosusone (1) and a new megastigmane glycoside epimer, 3-episedumoside F1 (9), together with thirteen known compounds including flavonoids (2-6), a 3-benzoxepine lactone (7), a pyridine-4,5-diol derivative (8), megastigmanes and megastigmane glycosides (10-15). Their structures were elucidated by means of high resolution-electrospray ionization (HR-ESI)-MS, one dimensional (1D) and two-dimensional NMR (2D-NMR) spectroscopy as well as comparison with the data reported in the literature. The cytotoxic effects on LU-1 (lung carcinoma), HepG2 (hepatocellular carcinoma), and MCF7 (breast carcinoma) cell lines were assessed. Prenylated chalcones 1-2 and isoflavone 3 exhibited cytotoxicity against all tested cell lines with IC50 values ranging from 22.04 to 45.03 µM.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::819d4cdcd4ed2f4665345a48a6e11506 https://doi.org/10.1248/cpb.c21-00614 Zobrazit plný text záznamu