ChemInform Abstract: ISOXAZOLES WITH ANTIPICORNAVIRUS ACTIVITY
Autor: | U. J. Salvador, C. J. Brisson, Guy D. Diana, E. S. Zalay, Mark A. McKinlay, J. V. Miralles |
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Rok vydání: | 1985 |
Předmět: | |
Zdroj: | Chemischer Informationsdienst. 16 |
ISSN: | 0009-2975 |
Popis: | The synthesis and evaluation of a series of 3,5-disubstituted isoxazoles as antipicornavirus agents have led to the discovery of several compounds effective in vitro against rhinovirus type 2 and poliovirus type 2. Compound 32 was found more effective than 4',6-dichloroflavan against both viruses and was evaluated orally in mice infected intracerebrally with polio-2. At 31 mg/kg bid, compound 32 showed a 53% survival rate as compared to 22% for the nonmedicated animals. |
Databáze: | OpenAIRE |
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