ChemInform Abstract: ISOXAZOLES WITH ANTIPICORNAVIRUS ACTIVITY

Autor:	U. J. Salvador, C. J. Brisson, Guy D. Diana, E. S. Zalay, Mark A. McKinlay, J. V. Miralles
Rok vydání:	1985
Předmět:	Chemistry medicine General Medicine Rhinovirus Poliovirus type medicine.disease_cause Virology Survival rate Compound 32 In vitro
Zdroj:	Chemischer Informationsdienst. 16
ISSN:	0009-2975
Popis:	The synthesis and evaluation of a series of 3,5-disubstituted isoxazoles as antipicornavirus agents have led to the discovery of several compounds effective in vitro against rhinovirus type 2 and poliovirus type 2. Compound 32 was found more effective than 4',6-dichloroflavan against both viruses and was evaluated orally in mice infected intracerebrally with polio-2. At 31 mg/kg bid, compound 32 showed a 53% survival rate as compared to 22% for the nonmedicated animals.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::819bbcc7e61fab6846136942c897d2ae https://doi.org/10.1002/chin.198544164 Zobrazit plný text záznamu Plný text