5-Iodo-1H-1,2,3-triazoles as Versatile Building Blocks

Autor:	Anastasia I. Govdi, Irina A. Balova, Natalia A. Danilkina
Rok vydání:	2020
Předmět:	Application areas 010405 organic chemistry Chemistry Organic Chemistry Halogen Bond formation 010402 general chemistry 01 natural sciences Combinatorial chemistry Catalysis Cycloaddition 0104 chemical sciences
Zdroj:	Synthesis. 52:1874-1896
ISSN:	1437-210X 0039-7881
DOI:	10.1055/s-0039-1690858
Popis:	Copper-catalyzed azide–alkyne cycloaddition is a useful tool for the synthesis of both 1,2,3-triazoles and 5-iodo-1H-1,2,3-triazoles starting from either terminal alkynes or iodoalkynes. 5-Iodotriazoles have been recognized as very useful building blocks for the synthesis of diverse 1,4,5-trisubstituted 1,2,3-triazoles. Synthetic application of 5-iodo-1,2,3-triazoles through the creation of a new C–C, C–heteroatom, or C–D(T) bond along with the application areas of both iodotriazoles and products of their modification including radiolabeled compounds are discussed.1 Introduction2 Synthetic Approaches to 5-Iodo-1H-1,2,3-triazoles3 5-Iodotriazoles in C–C Bond Formation3.1 Intermolecular C–C Cross-Coupling3.2 Intramolecular Cross-Coupling: Direct Arylation and C–I/C–I Homocoupling­3.3 Other Transformations4 5-Iodotriazoles in Radiolabeling, Halogen Exchange, and Heterocoupling Reactions5 Summary
Databáze:	OpenAIRE
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