Total synthesis of (S,S)-isodityrosine

Autor:	Laurie S. Starkey, Michael E. Jung
Rok vydání:	1997
Předmět:	chemistry.chemical_classification Nucleophilic addition Stereochemistry Aryl Organic Chemistry Iodide Total synthesis Biochemistry Amino acid chemistry.chemical_compound chemistry Cyclohexenone Drug Discovery Tyrosine Derivative (chemistry)
Zdroj:	Tetrahedron. 53:8815-8824
ISSN:	0040-4020
Popis:	The novel dimeric amino acid isodityrosine 1 has been synthesized by a route which uses a new method of diaryl ether preparation. Nucleophilic addition of a protected tyrosine to cyclohexenone oxide and the Pd(0)-catalyzed coupling of an aryl iodide with a protected iodoalanine derivative are the key steps in this synthesis. This represents one of the first efficient syntheses of this molecule beginning with two naturally-occurring amino acids as inexpensive starting materials
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8181ec6f9efd47834e10408fbbd6e8e5 https://doi.org/10.1016/s0040-4020(97)90393-8 Zobrazit plný text záznamu Full Text from ScienceDirect