HLA-DQA1 gene expression profiling in oligoarticular JIA

Autor:	Carola Frank, Johannes Peter Haas, M. Metzler, R. Wassmuth, R. Haefner
Rok vydání:	2009
Předmět:	musculoskeletal diseases Genetics Mutation endocrine system diseases biology Immunology nutritional and metabolic diseases Major histocompatibility complex medicine.disease_cause Gene expression profiling Gene expression biology.protein medicine Immunology and Allergy HLA-DQA1 Gene Oligoarticular Juvenile Idiopathic Arthritis Allele skin and connective tissue diseases Gene
Zdroj:	Autoimmunity. 42:389-391
ISSN:	1607-842X 0891-6934
DOI:	10.1080/08916930902832652
Popis:	Polymorphisms in the upstream regulatory region of the HLA class II DQA1 gene are currently defined by 10 different alleles. Two of them carrying a Y-box mutation are associated with susceptibility to oligoarticular juvenile idiopathic arthritis (OA-JIA). We investigated allele-dependent differences in HLA-DQA1 gene expression in OA-JIA patients. In cells from affected joints compared to peripheral blood, gene expression of HLA-DRA as well as total HLA-DQA1 was significantly upregulated. Differential analyses of HLA-DQA1 allelic expression showed DQA1*02 and *04 to be comparatively increased. Intra-articular upregulation of HLA-DQA1 was predominantly observed for the OA-JIA associated allele HLA-DQA1*04. Nevertheless, the Y-box mutation of the disease-associated allele DQA1*0401 was not a common denominator for expression behaviour.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::817ee66429ea4bb30054618a84466ecc https://doi.org/10.1080/08916930902832652 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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