Energy Drink Induced Lipid Peroxidation and Oxidative Damage in Rat Liver and Brain When Used Alone or Combined with Alcohol
| Autor: | Hande Sipahi, Ahmet Aydin, Rengin Reis, Mohammad Charehsaz, Asiye Işın Doğan Ekici, Hatice Akkaya, Caglar Macit |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
chemistry.chemical_classification medicine.medical_specialty Ethanol biology Glutathione peroxidase Alcohol Malondialdehyde medicine.disease_cause Superoxide dismutase Lipid peroxidation 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine Endocrinology Biochemistry chemistry Catalase Internal medicine medicine biology.protein 030217 neurology & neurosurgery Oxidative stress Food Science |
| Zdroj: | Journal of Food Science. 82:1037-1043 |
| ISSN: | 0022-1147 |
| Popis: | Energy drinks (ED) are containing large doses of metabolic stimulants and its use with ethanol has increased dramatically among young adults. In this study, we examined the effects of ED exposure either alone or in combination with ethanol on oxidative stress parameters including superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), and lipid peroxidation parameter malondialdehyde (MDA) in rat. Some histopathological findings were also evaluated. ED exposure led to a dose-dependent increase in liver MDA compared to the control indicating oxidative damage. Histopathological findings also revealed that ED alone may generate liver damage. Ethanol exposure increased MDA level and SOD, CAT, and GSH-Px activity in both the brain and the liver. The combination of ethanol and ED produced greater damage which is considered by further increases in SOD and GSH-Px activity in the brain. Similar results for MDA were observed in both the liver and brain as well. Our findings suggest that ED consumption alone or combination with ethanol may represent a significant public health concern. |
| Databáze: | OpenAIRE |
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