Aufnahme und Elimination von Hepatitis-B-Immunglobulin nach intramuskulärer Applikation

Autor:	Kuwert Ek, Scheiermann N
Rok vydání:	2008
Předmět:	Hepatitis B virus Viral antibody biology business.industry General Medicine Hepatitis B medicine.disease_cause Hepatitis B immunoglobulin medicine.disease Body weight Active immunization Virology medicine biology.protein Antibody business Intramuscular injection
Zdroj:	DMW - Deutsche Medizinische Wochenschrift. 107:1918-1922
ISSN:	1439-4413 0012-0472
DOI:	10.1055/s-2008-1070233
Popis:	After intramuscular administration of four different hepatitis B immunoglobulins at a dose of 0.1 ml/kg body weight, serum anti-HBs antibody titres were followed over four months in 37 healthy persons. Highest serum concentration averaged 138-355 mU anti-HBs/ml and was generally observed on the third or seventh day after passive immunisation. Immunoglobulins were eliminated with a half-life of 17.5-25 days. Four months after injections their concentration was still 1.2-2.5% of the maximally reached serum level. Intramuscular administration of hepatitis B immunoglobulin does not at once achieve effective optimal viral antibody levels in blood. But since there are no special preparations for intravenous use and active immunization is unlikely to be able to provide immediate protection against hepatitis B virus, intramuscular injection remains further on the method of choice in the prevention of hepatitis B after exposure.
Databáze:	OpenAIRE
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