(39) Decalin-type acetylcholine-mimetic organophosphates as inhibitors of acetylcholinesterase

Autor:	Fabrizio Gorla, Anthony Linden, Peter Rüedi, Stefan Furegati
Rok vydání:	2005
Předmět:	biology Chemistry Stereochemistry Kinetics General Medicine Decane Toxicology Acetylcholinesterase chemistry.chemical_compound Decalin medicine biology.protein Structure–activity relationship Molecule Acetylcholine medicine.drug Cholinesterase
Zdroj:	Chemico-Biological Interactions. :415-417
ISSN:	0009-2797
DOI:	10.1016/j.cbi.2005.10.084
Popis:	The novel decalin-type N,O,P-heterocycles, P(3)-axially and P(3)-equatorially substituted cis- and trans-configurated 3-fluoro-2,4-dioxa-7-aza-, 2,4-dioxa-8-aza-, and 2,4-dioxa-9-aza-3-phosphabicyclo[4.4.0]decane 3-oxides, are configuratively fixed and conformationally constrained phosphorus analogues of acetylcholine. The compounds are suitable probes for the investigation of molecular interactions with acetylcholinesterase.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::816720ac6afddc4dc01b8f3e2c661ca6 https://doi.org/10.1016/j.cbi.2005.10.084 Zobrazit plný text záznamu Full Text from ScienceDirect