| Popis: |
Relaxin is a two-chain peptide that shares several common features with insulin, such as size, chain structure and the cross-linking pattern. It is produced principally by the ovaries during pregnancy and has three major biological effects: (1) it decreases connective tissue formation (antifibrotic); (2) it promotes blood vessel formation (pro-angiogenic); and (3) it dilates blood vessels (vasodilatory). As a naturally occurring hormone, relaxin may serve as a treatment for a variety of disorders, such as infertility, peripheral arterial disease, cardiovascular disease, and other systemic diseases. The hormone is synthesised as a single-chain precursor, prorelaxin (as for insulin), and produced by proteolytic processing by enzymes [1]. |
