Lymphoid Leukosis in Chickens Chemically Bursectomized and Subsequently Inoculated with Bursa Cells 2

Autor:	H G Purchase, D G Gilmour
Rok vydání:	1975
Předmět:	endocrine system Cancer Research animal structures Synovial bursa Biology medicine.disease Virology Avian sarcoma virus Transplantation medicine.anatomical_structure Immune system Oncology embryonic structures Humoral immunity medicine Neoplasm Bursa of Fabricius Immunocompetence
Zdroj:	JNCI: Journal of the National Cancer Institute. 55:851-855
ISSN:	1460-2105 0027-8874
DOI:	10.1093/jnci/55.4.851
Popis:	Lymphoid leukosis (LL), a neoplasm of the bursa-dependent lymphoid cells of the chicken, was induced by Rous-associated virus-1 in susceptible chickens. Cyclophosphamide (CY), which destroyed the lymphoid elements of the bursa of Fabricius and abrogated humoral immunity, prevented LL. Concomitantly, osteopetorosis and other neoplasms increased. Transfer of bursa cells from chickens into CY-treated hatchmates restored immune competence. Birds whose B-cell functions were reconstituted died of LL and were less likely to die of osteopetrosis and other neoplasms than were CY-treated chicks. These results suggested that the bursa cell transferred into the CY-treated chicks were the target cells for lymphoid leukosis transformation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::815a375f301b22f1dfc49f3b902ad8e0 https://doi.org/10.1093/jnci/55.4.851 Zobrazit plný text záznamu