Unilateral ischemic preconditioning and heterologous preconditioning in living donor liver transplantation

Autor:	Giuliano Testa, Victoria Angelova, Leopoldo Laricchia-Robbio, Gregorio Chejfec, Enrico Benedetti, Tiffany Anthony, Damiano Rondelli
Rok vydání:	2009
Předmět:	Transplantation medicine.diagnostic_test business.industry medicine.medical_treatment Ischemia Heterologous Liver transplantation medicine.disease medicine.anatomical_structure Anesthesia Biopsy medicine Ischemic preconditioning Hepatectomy business Reperfusion injury Artery
Zdroj:	Clinical Transplantation. 24:334-340
ISSN:	1399-0012 0902-0063
DOI:	10.1111/j.1399-0012.2009.01075.x
Popis:	Ischemic preconditioning (IP) exerts a protective effect on tissues undergoing prolonged ischemia. No studies have been performed to assess the clinical impact of IP on normal human liver used for living donor transplantation (LDLT). Heterologous preconditioning (HP) protects liver tissue as demonstrated in a rat model. Our study investigates the impact that IP and HP have on the donor and recipient liver in LDLT. Twenty candidates for living donor right hepatectomy were divided in two groups. The study group underwent 10' unilateral ischemia by clamping the right portal vein and hepatic artery at the end of the parenchymal transection. Demographics, laboratory values, biopsy studies, IL-1Ra, Ki-67, and CytoDEATH stains were compared. The results show that 10' ischemia does not exert significant clinical and laboratory changes in living donor hepatectomy candidates.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8158ee86481c58e7dc6541fe254416e4 https://doi.org/10.1111/j.1399-0012.2009.01075.x Zobrazit plný text záznamu Plný text