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BAUMAN, R. A., J. J. WIDHOLM. S. GHOSH AND G. J. KANT Effects of chronic stress on delayed alternation performance in rats. PHYSIOL BEHAV 64 (4) 507–512, 1998.—The effects of sustained stress on acquisition and performance of a delayed alternation task were studied in male rats. Rats lived 24 h per day in operant cages where they earned all of their food via lever pressing. During the stress portion of each experiment, one group of rats was able to avoid or escape signaled intermittent footshock (Avoidance/Escape group), a second group (Yoked) did not have control over shock termination, a third group never received shock (Control). Shock trials were presented around-the-clock at approximately 5-min intervals and the stress portion of each study lasted 1 week. We have previously reported that rats tolerate this paradigm well and avoid/escape 99% of the shock trials. Three experiments were conducted. In Experiment 1, rats learned the delayed alternation task prior to stress onset; in Experiment 2, rats were exposed to stress and the alternation task concurrently; in Experiment 3, rats were stressed for 14 days prior to being required to perform the delayed alternation task. In the first experiment, stress decreased both food intake and the accuracy of responding during the first days of stress. In the second experiment (acquisition), stressed rats required more days to reach asymptotic performance on the alternation task. In Experiment 3, rats stressed for 14 days prior to acquisition of the delayed alternation task performed similarly to controls. |
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