Synthesis of 17α-bromovinyl- and 17α-iodovinylnortestosterone derivatives

Autor:	Henry Laurent, Paul-Eberhard Schulze, Rudolf Wiechert, Helmut Hofmeister
Rok vydání:	1986
Předmět:	Reaction conditions Norethisterone medicine.medical_treatment Organic Chemistry Acetal Tributyltin hydride Biochemistry Steroid chemistry.chemical_compound chemistry Derivative (finance) Drug Discovery medicine Organic chemistry Enone medicine.drug
Zdroj:	Tetrahedron. 42:3575-3578
ISSN:	0040-4020
DOI:	10.1016/s0040-4020(01)87323-3
Popis:	Depending upon the reaction conditions, norethisterone (1) and its ketal 2 can be transformed with tributyltin hydride to either the (E)-or(Z)-17α-(2-tributylstannylvinyl)-nortestosterone derivatives 3, 8 and 13. Further treatment with N-bromo- or N-iodosuccinimide yields the corresponding (E)- and (Z)-17α-halovinyl steroids 6,7,10 and 11. Radio-labelled (Z)-17α-(2-iodovinyl)-nortestosterone was prepared by reaction of the 17α-stannylvinyl derivative 13 with Na125I.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::81422ae22c1ed7e1d52e636c54400fe4 https://doi.org/10.1016/s0040-4020(01)87323-3 Zobrazit plný text záznamu