Immunodepressed Status of Mice after Bulbectomy
| Autor: | N. V. Bobkova, Olga V. Glushkova, N. I. Medvinskaya, O A Sinotova, A. N. Samokhin, Elena G Novoselova, V. B. Ogai |
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| Rok vydání: | 2004 |
| Předmět: |
Spleen
Biology medicine.disease General Biochemistry Genetics and Molecular Biology Nitric oxide Olfactory bulb chemistry.chemical_compound Immune system medicine.anatomical_structure chemistry Immunology medicine Splenocyte Macrophage Tumor necrosis factor alpha Alzheimer's disease General Agricultural and Biological Sciences |
| Zdroj: | Biology Bulletin. 31:613-619 |
| ISSN: | 1062-3590 |
| DOI: | 10.1023/b:bibu.0000049734.07925.d8 |
| Popis: | We studied the immune response in lymphoid cells of mice subjected to bilateral olfactory bulbectomy in comparison with sham-operated animals 1.5 and 13 months after surgery. The concentration of tumor necrosis factor decreased threefold in the peripheral blood of bulbectomized mice 1.5 months after surgery. Signs of immunodepression were also observed 13 months after surgery: suppression of mitogen-stimulated proliferation of T and B lymphocytes in the spleen, inhibition of synthesis of tumor necrosis factor in peritoneal macrophages and splenocytes, and decreased macrophage NO production. According to the immune status indices and our previous data on behavioral, biochemical, and morphological changes induced in bulbectomized mice, they have common symptoms with the Alzheimer's disease. This allows us to consider such animals as a model of sporadic form of this disease rather than of a depression. |
| Databáze: | OpenAIRE |
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