Epidermal growth factor receptor (EGFR) mutation testing is useful for primary lung cancer diagnosis and appropriate surgical resection: A case series
| Autor: | Kenji Ishii, Toru Bando, Atsushi Kitamura, Fumitsugu Kojima, K. Okafuji |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Lung medicine.diagnostic_test biology business.industry Cancer Papanicolaou stain medicine.disease Gastroenterology Surgical pathology medicine.anatomical_structure Bronchoscopy Internal medicine medicine biology.protein Adenocarcinoma Epidermal growth factor receptor Lung cancer business |
| Zdroj: | Respiratory Investigation. 60:171-175 |
| ISSN: | 2212-5345 |
| DOI: | 10.1016/j.resinv.2021.08.008 |
| Popis: | Primary lung cancer was suspected in three patients upon chest computed tomography (CT) and bronchoscopy. Wash cytology revealed that all patients had lesions categorized as class III or lower (Papanicolaou classification), and the wash solution was then subjected to an epidermal growth factor receptor (EGFR) mutation search. As a result, exon 19 deletion was found in two patients, whereas an exon 21 L858R mutation was found in one. Therefore, all three patients underwent surgery without pathological evidence, and surgical pathology subsequently confirmed the diagnosis of primary lung adenocarcinoma. As observed, EGFR mutation testing was useful for cancer diagnosis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect