Conjugation of Urinary Phenolic Steroids in the Nonpregnant Human Female with Particular Reference to Estrone Sulfate1
| Autor: | R. Hobkirk, P. R. Blahey, Mona Nilsen |
|---|---|
| Rok vydání: | 1969 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class Endocrinology Diabetes and Metabolism Urinary system Metabolite Biochemistry (medical) Clinical Biochemistry Estrone Estriol Urine Biochemistry chemistry.chemical_compound Endocrinology chemistry Estrone sulfate Estrogen Internal medicine medicine Sulfate |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 29:328-337 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jcem-29-3-328 |
| Popis: | The mode of conjugation of urinary metabolites of injected 17β-estradiol-6,7-3H was studied in 10 nonpregnant human females. Estrone was the major identified constitutent of a fraction released from conjugation by solvolysis and this “estrone sulfate” accounted for 2–65% of total urinary estrone. In one instance, in an apparently normal young female, estrone-3-sulfate was directly identified as a quantitatively major metabolite, exceeding the glucosiduronates of both estrone and estriol. The considerable “sulfate conjugation” of estrone and of other estrogen metabolites in this subject was apparently a reproducible finding. Besides estrone, 2-methoxyestrone was regularly identified in the subjects studied, as a component of the fraction released by solvolysis and this conjugated form accounted for up to 63% of total urinary 2-methoxyestrone. Endogenous urinary “estrone sulfate” in the normal menstrual cycle varied considerably between subjects and accounted for 0–71% of total estrone. Other metab... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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