Asparagine functionalized Al2O3 nanoparticle as a superior heterogeneous organocatalyst in the synthesis of 2-aminothiazoles
| Autor: | Zahra Shokrani, Zohre Zarnegar, Javad Safari |
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| Rok vydání: | 2019 |
| Předmět: |
Thermogravimetric analysis
010405 organic chemistry Chemistry Scanning electron microscope Organic Chemistry One-pot synthesis Nanoparticle 010402 general chemistry 01 natural sciences 0104 chemical sciences Analytical Chemistry Catalysis Inorganic Chemistry chemistry.chemical_compound Thiourea Yield (chemistry) Asparagine Spectroscopy Nuclear chemistry |
| Zdroj: | Journal of Molecular Structure. 1185:143-152 |
| ISSN: | 0022-2860 |
| DOI: | 10.1016/j.molstruc.2019.02.080 |
| Popis: | Asparagine functionalized aluminum oxide nanoparticles (Asp-Al2O3) have been prepared by a two-step procedure involving the grafting of Al2O3 with 3-chloropropyltrimethoxysilane (CPTMS) and subsequent organofunctionalization using asparagine amino acid. It is shown that Asp-Al2O3 exhibits as an active nanocatalyst for the preparation of 2-aminothiazoles is achieved by one-pot reaction of methylcarbonyls, thiourea and iodine. The structure of Asp-Al2O3 was characterized by fourier transform infrared radiation (FT-TR), thermal gravimetric analysis (TGA), X-ray diffraction (XRD), scanning electron microscopic (SEM), and energy-dispersive analysis of X-ray (EDAX) analyses. Advantages of this modified methodology include higher purity and excellent yield of products, greener and cleaner conditions, easy isolation of products and convenient manipulation. Moreover, immobilization of organocatalysts on the Al2O3 surface are stable under the catalytic reaction conditions resulting their efficient reuse. |
| Databáze: | OpenAIRE |
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