The opportunity of application of neurophysiological tests — schizophrenia endophenotypes for studying the role of genetic factors in cognitive processes in healthy subjects and in psychiatric diseases

Autor:	Z. I. Storozheva, A. V. Kirenskaya, F. O. Kibitov
Rok vydání:	2019
Předmět:	medicine.medical_specialty Endophenotype Schizophrenia (object-oriented programming) Healthy subjects medicine Cognition Neurophysiology Psychology Psychiatry
Zdroj:	V.M. BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY. :70-72
ISSN:	2313-7053
Popis:	The study of effects of genetic polymorphisms implicated in dopamine (COMT, DRD2) and GABA (GAD1) activities in the prefrontal cortex on antisaccades (AS) and evoked potential P300 measures was conducted with participation of 55 healthy subjects and 72 schizophrenic patients. The significant interaction of genotype and disease was found for most of the studied AS and P300 measures. The worse task performance and decreased efficacy of cortical activation were revealed for the associated with schizophrenia risk polymorphisms.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8132124a5cfe902fcfeacaf9d0938b49 https://doi.org/10.31363/2313-7053-2019-4-1-70-72 Zobrazit plný text záznamu