Titanocene-Catalyzed Cyclocarbonylation of o-Allyl Aryl Ketones to γ-Butyrolactones

Autor:	Natasha M. Kablaoui, Frederick A. Hicks, Stephen L. Buchwald
Rok vydání:	1997
Předmět:	Chemistry Aryl Substrate (chemistry) General Chemistry Charge-transfer complex Biochemistry Combinatorial chemistry Catalysis Reductive elimination chemistry.chemical_compound Electron transfer Colloid and Surface Chemistry Catalytic cycle Carbonylation
Zdroj:	Journal of the American Chemical Society. 119:4424-4431
ISSN:	1520-5126 0002-7863
Popis:	A method for the transformation of o-allyl aryl ketones to γ-butyrolactones using a catalytic amount of Cp2Ti(PMe3)2 or Cp2Ti(CO)2 is described. This catalytic “hetero Pauson−Khand”-type process proceeds via the carbonylation of an oxatitanacycle followed by thermally-induced reductive elimination to form a γ-butyrolactone and to regenerate the catalyst. We have investigated the scope and limitations of this catalytic methodology. Our results are consistent with the view that the key step in this catalytic cycle is formation of a charge transfer complex or involves reversible electron transfer between the catalyst and the substrate.
Databáze:	OpenAIRE
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