β2-Mikroglobulinurie bei Cytomegalievirus-Infektionen nach Nierentransplantation

Autor:	K. Sack, Jürgen Steinhoff, R. Preuss, G. Bein, A. Feddersen, W. G. Wood, Lutz Fricke
Rok vydání:	2008
Předmět:	medicine.medical_specialty business.industry Urinary system Beta 2-microglobulinuria Congenital cytomegalovirus infection General Medicine Urine medicine.disease Gastroenterology Excretion Transplantation Internal medicine medicine Prospective cohort study business Kidney transplantation
Zdroj:	DMW - Deutsche Medizinische Wochenschrift. 116:1008-1012
ISSN:	1439-4413 0012-0472
DOI:	10.1055/s-2008-1063709
Popis:	In a prospective study the occurrence of cytomegalovirus (CMV) infection was diagnosed by demonstrating CMV-immediate early antigen (IEA) in the blood in 13 out of 68 (19%) patients who had undergone renal transplantation (27 women, 41 men, mean age 46.3 [21-64] years). Twenty-four hour urine samples were collected at the same time for quantitative determination of selected marker proteins by immunoluminometric assays (IgG and transferrin as glomerular markers, alpha 1-microglobulin and beta 2-microglobulin as tubular markers). In all 13 confirmed cases of CMV infection there was an isolated rise in urinary beta 2-microglobulin excretion amounting to more than three times the normal. In 11 of the 13 cases the beta 2-microglobulinuria was noted before the CMV-IEA test became positive. This suggests that quantitative assay of beta 2-microglobulin in the urine may be of value in the early diagnosis of CMV infection--a matter of some prognostic importance--and may hence offer additional support for therapeutic decisions.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::812d8b79e73ab3100a514549789a7998 https://doi.org/10.1055/s-2008-1063709 Zobrazit plný text záznamu