A COMPARISON OF PHENYLPROPANOL (0.5%) WITH CHLOROFORM (0.25%) AND AN ADMIXTURE OF METHYL HYDROXYBENZOATE (0.06%) AND PROPYL HYDROXYBENZOATE (0.03%) AS PRESERVATIVES IN LIQUID MEDICINES

Autor:	Jane A. Goodall, J. Lyall, G. Smith, J. B. Murray, R. J. McBride
Rok vydání:	1980
Předmět:	Pharmacology chemistry.chemical_compound Preservative Chloroform Chromatography Propyl hydroxybenzoate chemistry Starch Tragacanth Pharmacology (medical) Methyl hydroxybenzoate Sterilization (microbiology) Hydroxybenzoates
Zdroj:	Journal of Clinical Pharmacy and Therapeutics. 5:323-327
ISSN:	1365-2710 0269-4727
DOI:	10.1111/j.1365-2710.1980.tb00976.x
Popis:	The effectiveness as a preservative in liquid medicines of phenylpropanol 0.5%, chloroform 0.25% and an admixture of methyl hydroxybenzoate 0.06% with propyl hydroxybenzoate 0.03% has been evaluated by determination of sterilization times. Phenylpropanol was as effective as chloroform against Escherichia coli and Staphylococcus aureus; in some mixtures phenylpropanol was more rapidly bactericidal than was chloroform against Pseudomonas aeruginosa. The admixture of hydroxybenzoates was a poor preservative. Problems in the preservation of paediatric chalk mixture were solved by the use of sterilized chalk and the replacement of tragacanth by derivatives of starch.
Databáze:	OpenAIRE
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