| Autor: |
Mekka R. Garcia, Lena Bell, Claire Miller, Devorah Segal |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Child Neurology Open. 9:2329048X2211469 |
| ISSN: |
2329-048X |
| DOI: |
10.1177/2329048x221146982 |
| Popis: |
The incidence of childhood central nervous system tumors in infants is about 6 per 100 000 children. Recent studies have showed recurrent fusion of the neurotrophic tyrosine receptor kinase (NTRK) gene in 10% of non-brainstem high grade glioma in very young children suggesting an oncogenic effect of the NTRK fusion genes. In this report, we present a rare, severe case of a full-term neonate who was noted to have widely splayed sutures and a bulging fontanelle at birth who was found to have infant-type hemispheric glioma with NTRK1 fusion with course complicated by seizures refractory to medical treatment. Patient was deemed a poor surgical candidate due to the size of the mass and thus parents opted for comfort care. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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