Effect of morphine on the concentration of monoamines in the emotiogenic zones of the hypothalamus in adult and old rats

Autor:	T. A. Dubilei
Rok vydání:	1997
Předmět:	medicine.medical_specialty Physiology Chemistry General Neuroscience Dopaminergic Serotonergic Ventromedial nucleus of the hypothalamus Endocrinology Monoamine neurotransmitter Hypothalamus Dopamine Internal medicine Monoaminergic medicine Serotonin medicine.drug
Zdroj:	Neurophysiology. 29:153-155
ISSN:	1573-9007 0090-2977
DOI:	10.1007/bf02463289
Popis:	The content of monoamines in the emotiogenic hypothalamic zones has been shown to noticeably change with aging of rats. The level of noradrenaline and serotonin increased in the ventromedial nucleus of the hypothalamus, while the concentration of noradrenaline increased in the lateral hypothalamic zone. Single i.p. injections of 10 mg/kg morphine evoked qualitatively different shifts in the monoamine concentrations in the hypothalamic emotiogenic zones of the rats of different ages: the level of dopamine increased in adult animals, while the levels of noradrenaline and serotonin dropped in old rats. It is supposed that in old age the effect of morphine on dopaminergic structures in the emotiogenic hypothalamic zones becomes more moderate, whereas that on the noradrenergic and serotonergic structures is facilitated. The age-related specificities of the morphine effect on the monoaminergic regulation of the emotiogenic hypothalamic zones can determine considerable modifications of a psychotropic effect of the drug in old age.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8126868a6f06ac4b04081a93869f0076 https://doi.org/10.1007/bf02463289 Zobrazit plný text záznamu Full text from SpringerLink