206 Increased urinary heparanase levels are associated with active lupus nephritis
| Autor: | B In-Woon, CS Cho, KJ Kim |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Creatinine business.industry Urinary system Glomerular basement membrane Lupus nephritis Heparan sulfate medicine.disease chemistry.chemical_compound Endocrinology medicine.anatomical_structure chemistry Internal medicine medicine Biomarker (medicine) Heparanase business Nephritis |
| Zdroj: | Poster Session. |
| DOI: | 10.1136/lupus-2017-000215.206 |
| Popis: | Background and aims Heparan sulfate in glomerular basement membrane is crucial for charge-selective filtration. Heparanase, an endoglycosidase that cleave heparan sulphate, is reported to be up-regulated in several proteinuric diseases. We investigated the association of urinary heparanase level with renal indices in patients with systemic lupus erythematosus (SLE). Methods Urinary samples were collected from 76 patients with lupus nephritis (LN; 51 active and 25 inactive), 63 SLE patients without renal involvement and 28 healthy individuals (HC). Heparanase levels were measured by ELISA and normalised by urinary creatinine level (mU/mg). Results Urinary heparanase levels were increased in SLE patients than HC (p 0.05). A cut-off value of 444 mU/mg predicted presence of active LN with sensitivity of 74.5% and specificity of 67.1%. Conclusions Urinary heparanase levels are increased in patients with active LN and reflect the activity of nephritis, indicating that urinary heparanase can serve as useful biomarker for active LN. |
| Databáze: | OpenAIRE |
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