| Autor: | Ravi Kumar Mn, Gupta Kc |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Drug
Materials science media_common.quotation_subject technology industry and agriculture Biomedical Engineering Biophysics Bioengineering macromolecular substances Controlled release Biomaterials Chitosan chemistry.chemical_compound Hydrolysis chemistry Phase (matter) PEG ratio Polymer chemistry medicine Swelling medicine.symptom Ethylene glycol Nuclear chemistry media_common |
| Zdroj: | Journal of Materials Science: Materials in Medicine. 12:753-759 |
| ISSN: | 0957-4530 |
| Popis: | Semi-interpenetrating polymer network (IPN) microspheres of chitosan and poly(ethylene glycol) PEG were prepared for controlled release of drugs. A new method for the chemical crosslinking of chitosan microspheres containing isoniazid (INH) as a model drug is proposed and evaluated. The method consists of the exposure of microspheres to the vapor of crosslinking agent that act in gaseous phase under mild conditions. The structural analysis of the microspheres was carried out by FTIR-analysis. The swelling behavior, hydrolytic degradation, structural changes of the microspheres and loading capacity (LC) of the microspheres for INH were investigated. The prepared microspheres have shown 93% drug loading capacity, which suggested that these semi-IPN microspheres are suitable for controlled release of drugs in an oral sustained delivery system. © 2001 Kluwer Academic Publishers |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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