The Renal Vascular Resistance and Renal Blood Flow of Hypothermic Machine Perfusion and Cold Storage in porcine slaughterhouse kidneys
| Autor: | Phornphop Naiyanetr, Goragoch Gesprasert, Tanit Kasantikul, Pimchanok Leelanukrom |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Machine perfusion business.industry 0206 medical engineering H&E stain Acute kidney injury Cold storage 02 engineering and technology 030230 surgery medicine.disease 020601 biomedical engineering Delayed Graft Function 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Anesthesia Renal blood flow Vascular resistance Medicine Histopathology business |
| Zdroj: | 2019 12th Biomedical Engineering International Conference (BMEiCON). |
| Popis: | Two commonly used organ preservation techniques are Hypothermic machine perfusion (HMP) and Cold storage (CS). This report presents a partial study of comparison of injured functional unit between Cold Storage and Hypothermic Machine Perfusion in porcine kidney by evaluated the renal vascular resistance (RVR) and histopathology report from hematoxylin and eosin (HE either HMP or CS, underwent 24 hours of preservation at 2°C. The data of RVR and RBF were retrieved after preservation hours, then histopathological examination was performed. Results, two out of three samples, HMP1 and HMP2, had higher RVR value more than at time zero (65.76 mmHg/mL/min and 828.60 mmHg/mL/min higher than 4.04 mmHg/mL/min and 6.97 mmHg/mL/min, respectively). While CS1 and CS2 had RVR value at time zero higher than after 24 hours (10.82 mmHg/mL/min and 9.11 mmHg/mL/min higher than 7.53 mmHg/mL/min and 3.22 mmHg/mL/min, respectively). Furthermore, the majority histopathology reports suggested a prominent effect of CS treatments on the cellular changes of the renal tubules than HMP treatments. Which concluded the HMP treatment was superior of the CS treatment, in term of reducing kidney injury, acute kidney injury (AKI) risk development and delayed graft function (DGF). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|