Effect of the Cytochrome P-1450IIE1 Genotype on Ethanol Elimination Rate in Alcoholics and Control Subjects

Autor: Yasuhiro Ueno, Hiroyuki Imamichi, Junko Adachi, Yoshitsugu Tatsuno, Akiyoshi Nishimura
Rok vydání: 1996
Předmět:
Zdroj: Alcoholism: Clinical and Experimental Research. 20:17a-21a
ISSN: 1530-0277
0145-6008
DOI: 10.1111/j.1530-0277.1996.tb01720.x
Popis: We studied an influence of genetic polymorphisms in the cytochrome P-450IIE1 (CYP2E1) gene on ethanol elimination rate in alcoholic patients and healthy subjects. The CYP2E1 genotype was determined by polymerase chain reaction-restriction fragment length polymorphism method for 124 alcoholics and 54 healthy subjects. There was no significant difference in the gene frequency of CYP2E1 between alcoholics and healthy control subjects. Blood ethanol concentrations in the 65 alcoholics on admission ranged from 0.32 to 4.22 mg/ml. In the patients with the c1/c2 genotype, the elimination rate was significantly correlated with blood ethanol concentration. In each of the three genotypes of CYP2E1, the patients were divided into three groups based on ethanol concentrations. The average of the ethanol elimination rate in the patients with c1/c2 having blood ethanol levels of ≥2.5 mg/ml was significantly higher than the rates in the two other groups of c1/c2. When blood ethanol levels were ≥2.5 mg/ml, the elimination rate in the patients with c1/c2 was significantly higher than that in those with c1/c1. Regardless of the CYP2E1 genotype, the elimination rate in the alcoholics was higher than that in the control subjects when blood ethanol levels were
Databáze: OpenAIRE
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