ClpC-Mediated Sporulation Regulation at Engulfment Stage in Bacillus anthracis

Autor:	Yogendra Singh, Nitika Sangwan, Chetkar Chandra Keshavam, Neha Dhasmana, Ekta Tyagi, Nishant Kumar, Aakriti Gangwal
Rok vydání:	2021
Předmět:	0106 biological sciences 0303 health sciences Protease biology medicine.diagnostic_test 030306 microbiology Proteolysis medicine.medical_treatment fungi Bacillus biology.organism_classification 01 natural sciences Microbiology Bacterial cell structure Bacillus anthracis Cell biology 03 medical and health sciences Metabolic pathway Clostridium 010608 biotechnology medicine Bacterial spore
Zdroj:	Indian Journal of Microbiology. 61:170-179
ISSN:	0973-7715 0046-8991
DOI:	10.1007/s12088-021-00927-5
Popis:	Bacterial sporulation is a conserved process utilized by members of Bacillus genus and Clostridium in response to stress such as nutrient or temperature. Sporulation initiation is triggered by stress signals perceived by bacterial cell that leads to shutdown of metabolic pathways of bacterial cells. The mechanism of sporulation involves a complex network that is regulated at various checkpoints to form the viable bacterial spore. Engulfment is one such check point that drives the required cellular rearrangement necessary for the spore assembly and is mediated by bacterial proteolytic machinery that involves association of various Clp ATPases and ClpP protease. The present study highlights the importance of degradation of an anti-sigma factor F, SpoIIAB by ClpCP proteolytic machinery playing a crucial role in culmination of engulfment process during the sporulation in Bacillus anthracis.
Databáze:	OpenAIRE
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