Cardenolide and bufadienolide derivatives of ajmaline

Autor:	V. V. Pavlova, Ya. I. Khadzhai, I. F. Makarevich, A. V. Nikolaeva
Rok vydání:	1979
Předmět:	Stereochemistry Alkaloid Plant Science General Chemistry Bufadienolide General Biochemistry Genetics and Molecular Biology Hellebrigenin chemistry.chemical_compound Ajmaline chemistry Bromide Halogen Cardenolide medicine Organic chemistry Strophanthidin medicine.drug
Zdroj:	Chemistry of Natural Compounds. 15:466-468
ISSN:	1573-8388 0009-3130
DOI:	10.1007/bf00565048
Popis:	A description is given of the synthesis of new compounds — 3-O-(ajmalin-N(b)-ioacetyl)strophanthidin and 3-O-(ajmalin-N(b)-ioacetyl)hellebrigenin bromides — possessing antiarrhythmic and cardiotonic activity. The synthesis was performed in two stages: 1) a preparation of halogen derivatives of the cardiac aglycones by acylating them with bromoacetyl bromide; and 2) the reaction of the alkaloid ajmaline with the halogen derivatives of the cardiac aglycones to quaternary salts.
Databáze:	OpenAIRE
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