Risk stratification and long-term risk prediction of E6 oncoprotein in a prospective screening cohort in China
Autor: | Ruimei Feng, Fang-Hui Zhao, Li Zhang, Xun Zhang, Qian Zhang, You-Lin Qiao, Jun-Fei Ma, Xuelian Zhao, Li Dong, Shang-Ying Hu, Rengaswamy Sankaranarayanan, Qin-Jing Pan |
---|---|
Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
Colposcopy Oncology Cervical cancer Gynecology Cancer Research medicine.medical_specialty medicine.diagnostic_test business.industry Prevalence Cervical intraepithelial neoplasia medicine.disease female genital diseases and pregnancy complications 03 medical and health sciences 030104 developmental biology 0302 clinical medicine 030220 oncology & carcinogenesis Liquid-based cytology Internal medicine Cohort Biopsy medicine Cumulative incidence business |
Zdroj: | International Journal of Cancer. 141:1110-1119 |
ISSN: | 0020-7136 |
Popis: | E6 oncoprotein is a necessary agent of HPV driven oncogenic transformation. This study is aimed at evaluating the risk stratification potency of HPV 16/18 E6 oncoprotein (E6) as a triage method for HPV positivity. Moreover, it also acts as a predictor of cervical intraepithelial neoplasia grade 3 or worse (CIN3+). The screening cohort of 1,997 women was followed for a 15 year period in approximate five-year intervals. Participants were concurrently screened by HPV DNA testing (HC2), liquid based cytology (LBC), visual inspection with acetic acid (VIA), and were referred to colposcopy and biopsy if any tests reflected positive. E6 was performed on cervical samples collected from this cohort in 2005 and 2014. The ability of E6 to predict CIN3+ risk after the five and ten year interval was evaluated. Among HPV positive women in 2005, E6 indicated the lowest positive rate (9.9%) compared to LBC (48.4%) and VIA (28.0%), however, a higher prevalence rate (10.3%) and ten year cumulative incidence rate (53.0%) of CIN3+ were detected among women who were E6 positive. Meanwhile, only approximately 4.2% and 2.9% of women with abnormal LBC and positive VIA were diagnosed as prevalent CIN3+ in 2005, 23.0% and 16.5% developed to CIN3+ after year ten, respectively. Strong associations were found between precedent and subsequent HPV persistence and E6 oncoprotein expression (ORadjusted=40.0 and 21.2 respectively). E6 oncoprotein can serve as a low-cost, highly specific, strongly indicative point-of-care method in the triage and treatment of HPV positive women. This article is protected by copyright. All rights reserved. |
Databáze: | OpenAIRE |
Externí odkaz: |