Humanized HLA-DQ8αβ transgenic mice treated with SEG/SEI superantigens exhibit long-term CD4+-mediated anti-tumor responses
| Autor: | Peter Leo Knopick, Travis D Alvine, Nivedita Biswas, Matthew L Nilles, David S Terman, David S Bradley |
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| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | The Journal of Immunology. 198:79.34-79.34 |
| ISSN: | 1550-6606 0022-1767 |
| Popis: | SEG and SEI are primordial S. aureus superantigens (SAgs) notably unaccompanied by human neutralizing antibodies that have hampered the use of classic SAgs as cancer therapeutics. Here we show SEG/SEI presented from a HLA-DQ8αβ (HLA-DQA*0301 and HLA-DQB*0302) tg platform outperform C57BL/6 mice in achieving long term survival in vaccinated and established Lewis lung carcinoma (LLC) and B16-F10 melanoma. Vaccination of DQ8 tg mice with LLC or B16-F10 melanoma followed by SEG/SEI immunization and subsequent tumor challenge resulted in 100% and 83% survival for >150 days respectively, compared to a median survival of 14 days in unvaccinated DQ8 tg controls (p |
| Databáze: | OpenAIRE |
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