Basic Science
| Autor: | R. Varkevisser, L. Nalos, M. K. B. Jonsson, G. Duker, T. P. De Boer, T. A. B. Van Veen, M. A. G. Van Der Heyden, M. A. Vos, P. Milberg, G. Frommeyer, S. Ghezelbash, L. Eckardt, B. O. Bingen, S. F. A. Askar, D. L. Ypey, A. Van Der Laarse, M. J. Schalij, D. A. Pijnappels, M. Mor, O. Beharier, D. Blumenthal, L. A. Gheber, A. Peretz, A. Katz, A. Moran, Y. Etzion, L. Uldry, N. Virag, J.- M. Vesin, L. Kappenberger, S. R. Marques-Neto, M. C. Pimenta, M. Marocolo-Junior, A. S. Maior, J. H. M. Nascimento, P. Flevari, G. Theodorakis, D. Leftheriotis, C. Kroupis, F. Kolokathis, K. Dima, D. Kremastinos, M. Anastasiou-Nana, H. Jowhari, F. Jaydari, M. Taati, A. Manteghi, R. Liew, K. B. Katwadi, Y. Gu, M. S. B. Mohamed Atan, K. T. Moe, B. Urbanek, J. Ruta, K. Kudrynski, K. Kaczmarek, M. Chudzik, P. Ptaszynski, J. K. Wranicz |
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| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Atrium (architecture) business.industry Atrial fibrillation medicine.disease Right atrial Free wall Rapid pacing Left atrial Physiology (medical) Anesthesia Internal medicine cardiovascular system Cardiology Medicine Cardiology and Cardiovascular Medicine business Cycle length |
| Zdroj: | Europace. 13:NP-NP |
| ISSN: | 1532-2092 1099-5129 |
| Popis: | Purpose: Experimental studies showed that local capture of atrial fibrillation (AF) by rapid pacing was possible in humans. However, contradictory observations were reported on its effect at distant atrial sites. The present model-based study investigated the effect of rapid pacing on the paced and the non-paced atria. Methods: A biophysical model of AF based on a geometry from human MRI and a membrane kinetics model was used. Rapid AF pacing was applied during 30s in right atrial (RA) free wall or left atrial (LA) appendage at optimal pacing cycle lengths based on previous studies (RA:76 ms, LA:77ms). The pacing effect was characterized by measuring 256 electrograms evenly located in RA and LA, from which the following values were computed: AF cycle length (AFCL), number of wavefronts (#WF), percentage of excited tissue (ET) and AF organization index (OI) assessing spectral regularity and ranging from 0 to 1. Results: Pacing successfully induced local AF capture in the paced atrium with an AFCL close to the pacing cycle length. Local capture was accompanied by a significant (p |
| Databáze: | OpenAIRE |
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