Effect of Derivatives of Hydroxamic Acids on Vasculogenic Mimicry
| Autor: | V. N. Osipov, A. V. Kolotaev, Yu. A. Khochenkova, A. N. Balaev, A. A. Vartanian, Dmitry Khochenkov, Yu. S. Machkova, K. A. Ohmanovich, D. S. Khachatryan |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Early necrosis Hydroxamic acid 010405 organic chemistry Organic Chemistry 01 natural sciences Biochemistry 0104 chemical sciences 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology chemistry In vivo Quinazoline Cancer research Vascular channel Vasculogenic mimicry Homeostasis Malignant phenotype |
| Zdroj: | Russian Journal of Bioorganic Chemistry. 46:252-263 |
| ISSN: | 1608-330X 1068-1620 |
| Popis: | Vasculogenic mimicry, the formation of vascular channels lined with tumor cells of a highly malignant phenotype, is currently considered as an additional system of blood supply of the tumor. Experimental studies in vivo have repeatedly demonstrated that vascular channels form in the areas of a tumor with a low density of blood vessels. It is supposed that the formation of a network of these channels inside the tumor maintains homeostasis and prevents early necrosis within it. In this work, bifunctional compounds based on a combination of quinazoline and hydroxamic acid in one molecule were examined for the ability to inhibit the migration of tumor cells and vasculogenic mimicry. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink