Absolute Bioavailability and Metabolism of Dodeca-2E,4E,8E,10E/Z-tetraenoic acid isobutylamides ('tetraene') after Intravenous and Oral Single Doses to Rats

Autor:	K. Wölkart, Rudolf Bauer, Veronika Butterweck, Reginald F. Frye, Hartmut Derendorf
Rok vydání:	2009
Předmět:	Echinacea (animal) biology Chemistry Echinacea purpurea extract Echinacea purpurea root extract Pharmaceutical Science Metabolism Pharmacology biology.organism_classification Absolute bioavailability
Zdroj:	Scientia Pharmaceutica. 77:195-195
ISSN:	0036-8709
DOI:	10.3797/scipharm.oephg.21.sl-28
Popis:	This study assessed the absolute and relative bioavailabilities of dodeca-2E,4E,8E,10E/Z-tetraenoic acid isobutylamides (tetraene), one of the main bioactive constituents in Echinacea, administered as pure compounds or as an Echinacea purpurea root extract preparation. Ten rats received 0.75 mg/kg dodeca-2E,4E,8E,10E/Z-tetraenoic acid isobutylamides oral, pure and within 158.6 mg/kg Echinacea purpurea extract, or intravenous.[...]
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::80cf01cd2dfac666b5b5b8db9be31d7a https://doi.org/10.3797/scipharm.oephg.21.sl-28 Zobrazit plný text záznamu