| Popis: |
Both human and animal studies are essential to revealing the mechanisms of pain processing, to identifying novel pain treatments, and to evaluating the effectiveness of pain management strategies. A cross-species approach to study pain can help us integrate data and findings obtained at different levels, thus advancing our understanding of pain and translating preclinical research into clinical programs. However, there are fundamental differences between species, which leads to nonnegligible discrepancies between human and animal studies. This brings great challenges in data interpretation and result comparison and integration. One possible solution to this problem is to discover translatable pain biomarkers across species. Gamma band oscillation (GBO) evoked by painful stimulus is one of the potential pain biomarkers, since it has been well-validated in both human and rodent studies. Using a cross-species approach, researchers are able to investigate the neural mechanisms and the regulating principles of GBO at different levels (microscopic—mesoscopic—macroscopic), which would benefit the translational research. On the other hand, it is necessary to acknowledge the differences between species and the influences of biological, psychological, and social variables when using a cross-species approach in pain research. |
