Combined Cytogenetic, FISH and RT-PCR Technique in Detection of t(15;17) and Monitoring of Minimal Residual Disease in Acute Promyelocytic Leukemia

Autor:	L. A. Vodinskaia, E. V. Domratcheva, Kuliev Rg, A. I. Udovitchenko, Demidova Ia, E. N. Parovitchnikova, Valeriy G. Savchenko, Yu V Olshanskaya, Andrey Sudarikov, Tiurina Ng
Rok vydání:	2001
Předmět:	Acute promyelocytic leukemia Leukemia Real-time polymerase chain reaction Fusion transcript business.industry medicine Cancer research Fish Chromosomal translocation T-15 medicine.disease business Minimal residual disease
Zdroj:	Haematology and Blood Transfusion / Hämatologie und Bluttransfusion ISBN: 9783642621093
DOI:	10.1007/978-3-642-18156-6_7
Popis:	Detection of the t(15;17) or PML/RARa rearrangment is important for analysis of clinical trials involving patients with suspected acute promyelocytic leukemia (APL). According to the majority of reports the translocation t(15;17)(q22;ql2–21) is detected in 70% to 100% of cases [1]. PML/RARa fusion transcript from add(15q) is beleived to play crucial role in leukemogenesis of this type of leukemia [2]. It’s presence remains the predictor of favourable prognosis and good response to modern modalities of therapy, especially ATRA [3].
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::80bc1e666a7c350aedb5b42889593bb8 https://doi.org/10.1007/978-3-642-18156-6_7 Zobrazit plný text záznamu