Copper-catalyzed diversified annulations between α-diketones and alkynyl α-diketones

Autor:	Xiangwen Kong, Jinggong Liu, Fang Yu, Fan Gong, Xinqiang Fang, Benlong Luo, Shengtong Niu, Shuang Yang
Rok vydání:	2022
Předmět:	chemistry.chemical_compound chemistry Nucleophile Waste production Furan Copper catalyzed chemistry.chemical_element Stereoselectivity General Chemistry Copper Combinatorial chemistry Catalysis
Zdroj:	Chinese Chemical Letters. 33:2997-3002
ISSN:	1001-8417
DOI:	10.1016/j.cclet.2021.11.070
Popis:	Copper-catalyzed divergent annulations between α-diketones and alkynyl α-diketones have been achieved, delivering a series of highly functionalized and biologically important cis-hexahydro-2H-cyclopenta[b]furan (HCPF) and 2-hydroxydihydrofuran-3(2H)-one (HDFO) products with high levels of stereoselectivity under identical conditions. The protocol features the use of earth-abundant copper catalyst, mild conditions, shortening synthetic routes in constructing different molecular frameworks, and reducing the corresponding possible waste production. The substituents of the nucleophilic α-diketones play crucial roles in switching the reaction pathways.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::80b13020265e9e795d8124f24c16999b https://doi.org/10.1016/j.cclet.2021.11.070 Zobrazit plný text záznamu Full Text from ScienceDirect