Effect of Gari Diet on Marker Enzymes of Mice Liver Mitochondria
| Autor: | I. G. Kalu, E. U. Ezeji, O. Obidua, I. N. Nwachukwu |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
chemistry.chemical_classification
Nutrition and Dietetics Succinate dehydrogenase Public Health Environmental and Occupational Health Biology Mitochondrion Enzyme assay Enzyme Biochemistry chemistry Respiration biology.protein Cytochrome c oxidase Respiratory control Food science Marker enzymes Food Science |
| Zdroj: | Pakistan Journal of Nutrition. 8:414-418 |
| ISSN: | 1680-5194 |
| DOI: | 10.3923/pjn.2009.414.418 |
| Popis: | 2 Abstract: Male and female albino mice were fed on maize (control) and gari (a dried cassava product) based diets for 5 weeks. Liver mitochondrial fractions were assayed for succinate dehydrogenase and Cytochrome C oxidase activities. There was an overall reduction in the activity of the two enzymes studied throughout the experiment. The reduction in activity was pronounced in Cytochrome c oxidase. Kinetic studies of succinate dehydrogenase showed an apparent increase in the Km of the gari fed animals-further supporting that inhibition took place. There was also a reduction in the mitochondrial respiratory control ratio (RCR) for the gari fed mice. The percentage reduction in RCR increased from 4.4% in the 2 week to about 45% in the 5 nd th week. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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