Comparison of immune profiles between hepatocellular carcinoma subtypes
| Autor: | Wentao Dai, Jia Li, Hong Li, Yuan-Yuan Li, Jia Fan, Bo Hu, Yixue Li, Fangyoumin Feng, Ping Lin, Xuemin Pan, Xin-Rong Yang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0303 health sciences
Mutation animal diseases medicine.medical_treatment Wnt signaling pathway Cancer chemical and pharmacologic phenomena General Medicine Immunotherapy biochemical phenomena metabolism and nutrition Biology medicine.disease_cause medicine.disease digestive system diseases 03 medical and health sciences 0302 clinical medicine Immune system 030220 oncology & carcinogenesis Hepatocellular carcinoma medicine Cancer research bacteria Carcinogenesis Gene 030304 developmental biology |
| Zdroj: | Biophysics Reports. 6:19-32 |
| ISSN: | 2364-3420 2364-3439 |
| Popis: | Immunotherapy, especially immune checkpoint inhibitors, is becoming a promising treatment for hepatocellular carcinoma (HCC). However, the response rate remains limited due to the heterogeneity of HCC samples. Molecular subtypes of HCC vary in genomic background, clinical features, and prognosis. This study aims to compare the immune profiles between HCC subtypes and find subtype-specific immune characteristics that might contribute to the prognosis and potential of immunotherapy. The immune profiles consist of immune-related genes, cytolytic activity, immune pathways, and tumor-infiltrating lymphocytes. HCC-c1 samples showed an overall higher activation level of immune genes and pathways, and this pattern was consistent in validation sets. We associated the difference in immune profiles with the activation level of cancer hallmarks and genomic mutations. There was a negative correlation between most of the metabolism pathway and immune-related pathways in HCC samples. CTNNB1/WNT signaling pathway mutation, one of the common mutations in HCC, appears to be associated with the expression of immune genes as well. These results reveal the difference of immune profiles between HCC subtypes and possible reasons and influence, which may also deepen our understanding of the carcinogenesis process. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink