The effect of endocervical and catheter bacterial colonisation during in vitro fertilisation and embryo transfer (IVF-ET) on IVF success rate among asymptomatic women: a longitudinal prospective study
Autor: | Kamran Hessami, Mahtab Hadadi, Mohammad Motamedifar, Nahid Homayoon, Sara Davoodi, Hamide Homayoon, Atefe Hashemi, Samane Mohebi, Behnaz Razavi, Leila Ghasempour, Shaghayegh Moradi Alamdarloo, Alamtaj Samsami |
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Rok vydání: | 2021 |
Předmět: |
Pregnancy
medicine.medical_specialty 030219 obstetrics & reproductive medicine In vitro fertilisation Microbiological culture business.industry Obstetrics medicine.medical_treatment Obstetrics and Gynecology medicine.disease Asymptomatic Embryo transfer 03 medical and health sciences Catheter 0302 clinical medicine 030220 oncology & carcinogenesis medicine Endometritis medicine.symptom business Prospective cohort study |
Zdroj: | Journal of Obstetrics and Gynaecology. 42:333-337 |
ISSN: | 1364-6893 0144-3615 |
Popis: | The adverse effects of bacterial contamination during in vitro fertilisation and embryo transfer (IVF-ET) have been studied previously. However, data on asymptomatic women with positive bacterial culture and their IVF outcome are lacking. This prospective longitudinal study was conducted on 74 women undergoing IVF-ET, of whom specimens from the endocervix and ET catheter were taken and sent to a laboratory for microbiological assessment. Then, patients were followed up for evaluation of chemical pregnancy (β-HCG > 25 mIU/mL) and clinical pregnancy (detected foetal heartbeat). The findings revealed that there was no significant difference in terms of biochemical (35.4% vs. 19.2%, p= .116) and clinical pregnancy rate (25.0% vs. 15.4%, p= .257) among ET catheter culture positive and negative women. This finding allows us to conclude that the positive culture in the absence of clinical signs of infection may not increase the risk of implantation failure.Impact StatementWhat is already known on this subject? There is growing evidence indicating that endometritis may decrease the endometrial receptiveness in in vitro fertilisation (IVF) cycles; however, there is a paucity of knowledge regarding IVF outcomes when the bacterial culture of embryo transfer (ET) catheter is positive.What the results of this study add? The present study demonstrates that positive ET catheter culture in asymptomatic women does not increase the risk of IVF failure.What the implications are of these findings for clinical practice and/or further research? Positive-culture, per se, may not be associated with poor IVF outcomes and further studies should be undertaken on this topic in various clinical settings using different protocols. |
Databáze: | OpenAIRE |
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