Photocatalyst-Free, Visible-Light-Mediated C(sp3)–H Arylation of Amides via a Solvent-Caged EDA Complex

Autor:	Jaspreet Kaur, A. Shahin, Joshua P. Barham
Rok vydání:	2021
Předmět:	010405 organic chemistry Organic Chemistry Substrate (chemistry) 010402 general chemistry Photochemistry Persulfate 01 natural sciences Biochemistry 0104 chemical sciences Solvent chemistry.chemical_compound chemistry Amide Photocatalysis Physical and Theoretical Chemistry Visible spectrum
Zdroj:	Organic Letters. 23:2002-2006
ISSN:	1523-7052 1523-7060
DOI:	10.1021/acs.orglett.1c00132
Popis:	A photocatalyst-free and mild visible light photochemical procedure for C(sp3)-H arylation of amides is described. The reaction proceeds via an electron donor-acceptor (EDA) complex between an electron-rich arene substrate and electron-poor persulfate oxidant. C(sp3)-H arylation of the amide occurs selectively with the most electron-rich arene of the substrate. Mechanistic studies corroborate the reaction taking place in a solvent cage holding components in a close proximity.
Databáze:	OpenAIRE
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