Asymmetrically induced alkylation of 2-benzyl-4-isopropyl-2,4-dihydro-1H-pyrazino[2,1-b]quinazoline-3,6-dione

Autor:	Félix L. Buenadicha, Carmen Avendaño, Mónica Söllhuber
Rok vydání:	1998
Předmět:	Inorganic Chemistry chemistry.chemical_compound chemistry Stereochemistry Organic Chemistry Quinazoline Proton NMR Stereoselectivity Physical and Theoretical Chemistry Alkylation Catalysis Isopropyl Stereocenter
Zdroj:	Tetrahedron: Asymmetry. 9:4275-4284
ISSN:	0957-4166
DOI:	10.1016/s0957-4166(98)00464-9
Popis:	The substitution of the 4-methyl group by a 4-isopropyl group in the 2-benzyl-2,4-dihydro-1H-pyrazino[2,1-b]quinazoline-3,6-dione system allows a notable improvement in the stereoselective alkylation at C-1. The configuration of the newly introduced stereogenic centre has been assigned on the basis of 1H NMR data and NOE measurements.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::807e00aec6a283244930af5e140cb7f4 https://doi.org/10.1016/s0957-4166(98)00464-9 Zobrazit plný text záznamu Full Text from ScienceDirect