Water Molecules Allow the Intramolecular Activation of the Thiamine Di-Phosphate Cofactor in Human Transketolase: Mechanistic Insights into a Famous Proposal
| Autor: | Mario Prejanò, Fabiola E. Medina |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
chemistry.chemical_classification
biology 010405 organic chemistry food and beverages General Chemistry Transketolase 010402 general chemistry Phosphate 01 natural sciences Catalysis Cofactor 0104 chemical sciences QM/MM chemistry.chemical_compound Enzyme chemistry Biochemistry Intramolecular force biology.protein Molecule Thiamine human activities |
| Zdroj: | ACS Catalysis. 11:4136-4145 |
| ISSN: | 2155-5435 |
| DOI: | 10.1021/acscatal.0c05414 |
| Popis: | Thiamine diphosphate-dependent enzymes are central to a wide range of technological areas and fields of science. The activity of these enzymes is closely related to the presence of the thiamine dip... |
| Databáze: | OpenAIRE |
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