Translocation 4; 11 in acute lymphoblastic leukemia: clinical characteristics and prognostic significance
| Autor: | Clara D. Bloomfield, Leanna L. Lindquist, Mark E. Nesbit, Diane C. Arthur |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
medicine.medical_specialty
business.industry Immunology Induction chemotherapy Karyotype Liter Chromosomal translocation Cell Biology Hematology medicine.disease Biochemistry Gastroenterology Surgery Leukemia Regimen medicine.anatomical_structure Internal medicine medicine Bone marrow Leukocytosis medicine.symptom business |
| Zdroj: | Blood. 59:96-99 |
| ISSN: | 1528-0020 0006-4971 |
| Popis: | Banded bone marrow chromosome analyses have been done on 83 unselected patients with acute lymphoblastic leukemia (ALL). Seven patients, all with non-T, non-B ALL, had a translocation involving the long arms of chromosomes 4 and 11. Five of these patients, 4 children and 1 adult, were first studied at diagnosis, and the t(4;11) (q21;q23) was the only karyotypic abnormality. All 5 presented with a marked leukocytosis (greater than 150 X 10(9)/liter). Four of these 5 patients achieved a complete remission following the same intensive treatment regimen; however, remission duration and survival were very short (medians 2.5 and 8 mo, respectively). The fifth patient is currently receiving induction chemotherapy. The remaining 2 patients, both adults, were studied in relapse only, and had other karyotypic abnormalities in addition to the t(4;11). One of these relapse patients was a female whose clinical presentation and course were similar to those above. The last patient was a male who presented with a leukocyte count of 7 X 10(9)/liter and maintained an initial complete remission for 37 mo. Our data suggest that patients who have a t(4;11) (q21;q23) at the time of diagnosis of ALL have a poor prognosis with conventional therapy and require a new therapeutic approach. |
| Databáze: | OpenAIRE |
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