Renal oncocytoma with adverse pathologic features: a clinical and pathologic study of 50 cases
| Autor: | Khaleel I Al-Obaidy, Liang Cheng |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty business.industry medicine.medical_treatment urologic and male genital diseases medicine.disease Nephrectomy Pathology and Forensic Medicine Adipose capsule of kidney Metastasis Renal neoplasm 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure 030220 oncology & carcinogenesis Keratin 7 medicine Renal vein Renal oncocytoma business Renal sinus |
| Zdroj: | Modern Pathology. 34:1947-1954 |
| ISSN: | 0893-3952 |
| Popis: | Renal oncocytoma is the most common benign epithelial renal neoplasm. Several adverse features that would typically increase the stage of renal cell carcinomas are not uncommon in renal oncocytoma, including perinephric, sinus fat, or renal vein invasion. Herein, we report the largest single institutional series of renal oncocytoma with adverse pathologic features. The cohort comprised 50 patients, 38 were men (76%) and 12 were women (24%), with a mean age of 68 years (range, 50-87 years). All cases were diagnosed on nephrectomy specimens. No laterality predilection was noted. The tumors ranged in size from 1.5-15.7 cm (mean, 5.3 cm). Adverse pathologic features included perinephric fat invasion (n = 25; 50%), renal sinus fat invasion (n = 9; 18%), and renal vein invasion (n = 5; 10%). More than one adverse feature was seen in 11 tumors (22%). All tumors showed diffuse reactions to KIT (n = 40; 100%) and cyclin D1 (n = 27; 100%). Keratin 7 highlighted rare ( |
| Databáze: | OpenAIRE |
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