The Strength and Compaction of Millispheres: The design of a controlled-release drug delivery system for ibuprofen in the form of a tablet comprising compacted polymer-coated millispheres

Autor:	M. E. Aulton, K. A. Khan, A. M. Dyer
Rok vydání:	1994
Předmět:	Pharmacology chemistry.chemical_classification Materials science Organic Chemistry Pellets Pharmaceutical Science Core (manufacturing) Polymer engineering.material Ibuprofen Rheology chemistry Coating Drug Discovery Drug delivery engineering medicine Extrusion Composite material medicine.drug
Zdroj:	Drug Development and Industrial Pharmacy. 20:3069-3104
ISSN:	1520-5762 0363-9045
DOI:	10.3109/03639049409041969
Popis:	This paper reviews a case study of the design of a controlled-release drug delivery system for ibuprofen in the form of a tablet comprising compacted polymer-coated millispheres (multiparticulate pellets). The particular challenge was to prepare coated millispheres of ibuprofen (a high-dose drug) with the addition of minimal excipients so that the drug-release retarding polymeric membrane surrounding the millispheres remains intact during and after tablet compression, disintegration and release of the millispheres. The study included (a) the design of the uncoated core and its manufacture by wet massing, extrusion, spheronization and drying; (b) the coating of these millispheres with a range of possibly suitable polymers; (c) an assessment of the drug release profiles from these pellets; (d) the quantification by indentation rheology of the mechanical properties of the polymer films used to coat the spheres; (e) the measurement of the mechanical properties of individual uncoated and coated millisp...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::807062ddf351b12b0203ca4adc45237c https://doi.org/10.3109/03639049409041969 Zobrazit plný text záznamu