Mechanical Composites of Rimantadine and Larch Arabinogalactan

Autor:	A. A. Levchuk, N. A. Neverova, A. N. Sapozhnikov, V. A. Babkin, E. N. Medvedeva
Rok vydání:	2014
Předmět:	biology Rimantadine Chemistry Infrared spectroscopy Plant Science General Chemistry biology.organism_classification General Biochemistry Genetics and Molecular Biology Amorphous solid Arabinogalactan medicine Larch Composite material medicine.drug
Zdroj:	Chemistry of Natural Compounds. 50:225-229
ISSN:	1573-8388 0009-3130
DOI:	10.1007/s10600-014-0918-8
Popis:	Mechanical composites were produced by mechanochemical treatment of a mixture of the antiviral drug rimantadine and arabinogalactan (AG) isolated from larch wood. Their properties were studied using PMR, 13C and 15N NMR, and IR spectroscopy. It was found that AG and rimantadine did not react chemically under the studied conditions. The mechanical treatment decreased the size of crystalline rimantadine particles and produced amorphous material according to x-ray diffraction analysis. The mechanochemical treatment dispersed rimantadine in the AG matrix.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::806d4b673736ee3d17073d864bdf95bb https://doi.org/10.1007/s10600-014-0918-8 Zobrazit plný text záznamu Plný text ve formátu PDF