Porous silicon nanoparticles as scavengers of hazardous viruses
| Autor: | S. N. Shevchenko, E.V. Karamov, V.N. Nikiforov, Konstantin Tamarov, M. B. Gongalsky, V. Yu. Timoshenko, Liubov A. Osminkina, Musa Khaitov, G.V. Kornilaeva, Igor Shilovsky, Sergey S. Abramchuk |
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| Rok vydání: | 2014 |
| Předmět: |
Materials science
Silicon viruses Human immunodeficiency virus (HIV) chemistry.chemical_element Nanoparticle Bioengineering General Chemistry Condensed Matter Physics medicine.disease_cause Porous silicon Atomic and Molecular Physics and Optics In vitro Virus Viral envelope chemistry Modeling and Simulation medicine Nanomedicine General Materials Science Nuclear chemistry |
| Zdroj: | Journal of Nanoparticle Research. 16 |
| ISSN: | 1572-896X 1388-0764 |
| Popis: | We report that silicon nanoparticles (SiN- Ps) with typical sizes from 5 to 50 nm prepared by grinding of porous silicon can act as efficient scavengers of human immunodeficiency virus (HIV) and respiratory syncytial virus (RSV). In vitro studies have revealed a strong suppression of the viral activity in the presence of SiNPs with concentration above 0.1 and 0.01 mg/mL for HIV and RSV, respectively. The observed effect is explained by binding of the virions with SiNPs that is supposed to be universal for different enveloped viruses. Because of the cytotoxic concentration of SiNPs is of the order of 1 mg/mL, SiNPs can be proposed for applications in new harmless methods of antiviral treatment. |
| Databáze: | OpenAIRE |
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