Fluorometric Screening Method for Detecting Benzodiazepines in Blood and Urine

Autor:	Joseph R. Monforte, James C. Valentour, Beverly Lorenzo, Irving Sunshine
Rok vydání:	1975
Předmět:	Chromatography Oxazepam Chemistry Biochemistry (medical) Clinical Biochemistry Screening method medicine Urine Pharmacology Chlorazepate Diazepam Chlordiazepoxide medicine.drug
Zdroj:	Clinical Chemistry. 21:1976-1979
ISSN:	1530-8561 0009-9147
Popis:	We report a fluorometric method for detecting diazepam, chlordiazepoxide, oxazepam, chlorazepate, and (or) their major metabolites in blood, urine, or gastric contents at low therapeutic concentrations. The drugs are first hydrolyzed to their respective benzophenones and converted to highly fluorescent 9-acridanones. Total benzodiazepines (parent plus metabolites) in blood and gastric contents are semiquantitatively evaluated and compared to results of gas-chromatographic determinations.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8066c375baaf40f225249b2b567d07f2 https://doi.org/10.1093/clinchem/21.13.1976 Zobrazit plný text záznamu